Powering Epigenetics through the 1C Pathway

Silibinin protects β cells from glucotoxicity through regulation of the Insig-1/SREBP-1c pathway.

Exposure to high glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction including cell apoptosis, impaired glucose‑stimulated insulin secretion (GSIS) and intracellular lipid accumulation. Sterol regulatory element binding protein-1c (SREBP-1c), a key nuclear transcription factor that regulates lipid metabolism, has been proven to play a role in insulin secretion. Insulin ind...

KGF induces lipogenesis in alveolar type II cells through a SREBP-1c dependent pathway

Keratinocyte growth factor (KGF) stimulates fatty acid and phospholipid synthesis in alveolar type II cells in vitro. KGF stimulates lipogenic enzymes including fatty acid synthase and stearoyl-CoA desaturase-1 and transcription factors involved in lipogenesis such as SREBP-1c and C/EBPα and C/EBPδ. To define the role of SREBP-1c on the induction of lipogenic genes and lipogenesis by KGF in pri...

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.

In the present study, we aimed to decipher the mechanisms involved in the transcriptional effect of insulin on the SREBP-1c specific promoter of the human srebf-1 gene. Using luciferase reporter gene constructs in HEK-293 cells (human embryonic kidney cells), we demonstrated that the full effect of insulin requires the presence of SREs (sterol response elements) in the proximal region of the pr...

The Prospects of Epigenetics in Neuroscience

Powering the porter brewery.

Before canals and railways developed as a major transport network, it was seldom profitable to transport beer inland over more than a few miles. In country towns and villages, therefore, beer would be brewed either by a small 'common' brewery that supplied a handful of pubs and private customers, or in an even smaller brew-house attached to the pub itself. Many families also brewed their own be...